Microdosing Psychedelics: A Comparative Guide to Unlocking Potential

At Kosha Coaching, we view microdosing as a powerful, natural pathway to elevate creativity, sharpen cognition, and overcome psychological barriers like low mood or anxiety. By gently integrating these tools into your routine, you can shift away from reliance on alcohol or antidepressants toward sustained physical and mental vitality. Below is a comparison chart of microdosing effects for psilocybin, LSD, mescaline, and MDMA, drawn from scientific reviews, studies, and user experiences. Remember, effects vary individually—start low, consult professionals, and adhere to laws. While classic psychedelics like psilocybin, LSD, and mescaline offer high-benefit, low-risk profiles for subtle enhancements, MDMA's entactogen nature introduces more caution due to potential neurotoxicity.

Explore how microdosing can elevate creativity, cognition, and emotional well-being with a high-benefit, low-risk approach.

Aspect 🍄 Psilocybin (Mushrooms) 🌀 LSD 🌵 Mescaline (Peyote/San Pedro) 💊 MDMA
Typical Microdose 0.1–0.3g dried (10–30mg psilocybin) 10–30µg 35–75mg 5–20mg
Duration of Effects 3–6 hours 6–8 hours 10–12 hours 2–4 hours
Key Effects & Benefits Mood uplift, creativity boost, introspection, emotional flexibility, enhanced focus, reduced anxiety/depression, neuroplasticity for habit change. Enhanced focus/productivity, energy, mental clarity, creativity, reduced depression. Heightened focus/energy, sensory enhancement, emotional warmth/empathy, grounded introspection. Mood/empathy boost, social connection, emotional openness; anecdotal relief from PTSD/anxiety.
Potential Risks Very low: Mild discomfort if overdosed; low toxicity, no addiction. Low: Possible anxiety; tolerance with frequent use. Low-moderate: Nausea, mild cardiovascular effects. Higher: Neurotoxicity, serotonin depletion, cardiovascular strain.
Research & Notes Strong evidence for mental health; promotes neuroplasticity. Ideal gentle on-ramp. Well-studied for energy and mood. Less common; similar to classics with heart-centered effects. Anecdotal; higher risks—not for routine microdosing.

Always consult a professional, check local laws, and start low for safe exploration.

This chart highlights how microdosing can be a gentle tool for personal growth, with psilocybin and LSD leading in accessibility and research-backed benefits for daily enhancement. Mescaline offers a unique, grounded empathy, while MDMA's social focus comes with caveats—consider it sparingly. Always prioritize set, setting, and integration for optimal results, and explore our training program for guided steps toward vibrant health.